Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis and structural studies on penta and hexa coordinated organotin (IV) complexes of alkyl pyruvate aroyl hydrazones

Author(s): Sonika, Nidhi and R. Malhotra

A series of five and six coordinated diorganotin(IV) complexes of the type R2Sn(L)n Cl2-n [R = butyl and phenyl, n = 1 or 2, HL = Schiff base derived from the condensation of methyl/ethyl pyruvate with substituted acid hydrazides [salicylhydrazide, p-toluic acid hydrazide and napthoic acid hydrazide] have been synthesized. The mode of bonding in the complexes has been suggested on the basis of analytical and spectroscopic techniques (IR, 1H, 13C and 119Sn NMR) spectra, where the ligands are coordinating to metal through oxygen and nitrogen of carbonyl and azomethine group respectively. The ligands and their organotin complexes have been tested for antimicrobial activity against phytopathogenic fungi Candida albicans, Aspergillus niger at 25±1°C and bacteria Bacillus subtilis, Escherichia coli and Staphylococcus aureus at 37±1°C compared with Tetracycline, Chloramphenicol, Kanamycin, Cefazolin Sodium, Cefotaxime as reference drugs. The activity of the ligands is enhanced on complexation.


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