Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis and study of (5Z)-5-[(4-oxo-4H-chromen-3-yl) methylidene]-1, 3- thiazolidine-2, 4-dione derivative

Author(s): Ashish L. Asrondkar, Vrushali N. Patil, Neha U. Mishra, Anil S. Bobade and Abhay S. Chowdhary

Thiazolidinone was synthesized by using Thiourea and chloroethylacetate. Chromene derivative were synthesized by Vilsmeier-Hack reaction using substituted Hydroxy Benzoic Acid. Initially synthesized Thiazolidinone and Chromene derivative were condensed using alcohol as a solvent. Further synthesized compounds were characterized by elemental & spectroscopic analysis. Compounds were further evaluated for in-vitro Anti- Inflammatory activity.