Aroyl/alkoylacetophenones (2a-b) undergoes intramolecular claisen condensation to form 1-(2’- hydroxy-3’,5’-dichlorophenyl)-3-aryl/alkyl-1,3-propanediones (4a-b) which on treatment with aromatic and aliphatic aldehydes in ethanol containing little piperidine forms 3-aroyl/alkoylchromanones (5ab) subsequently 3-aroyl/ alkoylchromones (6a-b). 3-Aroyl/alkoylchromones (6a-b) on treatment with Ph.NH.NH2.HCl in DMSO containing small amount of piperidine gave 4-aroyl/alkoylpyrazoles (7a-b).So also 3-aroyl/alkoylchromones (6a-b) on treatment with NH2OH.HCl in DMSO containing a small amount of piperidine gave 4-aroyl/ alkoylisoxazoles (8a-b). The structures of newly synthesized chlorosubstituted 4-aroyl/alkoyl- pyrazoles (7a-b) and 4- aroyl/alkoylisoxazoles (8a-b) were elucidated on the basis of molecular weight, elemental analysis and their spectral data.
Select your language of interest to view the total content in your interested language
Der Pharma Chemica received 11575 citations as per Google Scholar report