GET THE APP

Synthesis, antimicrobial activities and structure activity relationship of some dithiocarbazinate, 1,2,4-triazoles and 1,2,4-triazolo[3,4b][1,3,4]thiadiazoles | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

ilbet

süperbetin giriş

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

agariookey oyna istanbul okey

Abstract

Synthesis, antimicrobial activities and structure activity relationship of some dithiocarbazinate, 1,2,4-triazoles and 1,2,4-triazolo[3,4b][1,3,4]thiadiazoles

Author(s): Surendra N Pandeya, AmitChattree and Iffat Fatima

The reaction of substituted benzoic acid hydrazide with carbondisulfide and potassium hydroxide followed by treatment with hydrazinehydrate afforded 4-amino-5-aryl-4H-1, 2, 4-triazole-3-thiol (4). Condensation of (4) with various aromatic carboxylic acids in the presence of phosphorus oxy chloridegives 3,6disubstituted- [1,2,4]triazolo[3,4b][1,3,4]thiadiazoles(5) and with various aroylthiocyanate in the presence of ethanol gives N,3 disubstituted-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-amine (6). The structure of these newly synthesized compounds was characterized by elementalanalysis, IR, 1H NMR studies. All the synthesized compoundswere screened for their antibacterial activity against H.pylori, P.aeroginosa, E.coli, S.aureus and Methcyclin resistant strain(MRSA) and antifungal activity against A.niger, A.foeniculum and P.chrysogenum. Some of compounds exhibited promising antibacterial and antfungal activities.Most active antifungalcompound was4a (4-amino-5- phenyl-4H-1, 2, 4-triazole-3-thiol) with MIC (Minimum Inhibitory Concentration) 57.14 μg/ml and Zone of inhibition 14 mmagainst A.foeniculum. Most potent antibacterial compound was5b (3-(4-nitrophenyl)-6-phenyl-[1, 2, 4]-triazolo [3, 4-b] [1, 3, 4] thiadiazole) with MIC 10 μg/ml, Zone of inhibition 8mmagainst H.pylori.


PDF

rokettube brazzers

https://pmasites.com/https://casinositeleriniz.com/https://fbhesq.com/

https://paperio-live.com

wowcappadocia.com
cappadocia-hotels.com
https://babesoflondon.com/
balloon-rides.net

wormax io