In recent days, spread of fungal, viral and microbial infections and their resistance to antibiotics compel us to develope new, powerful and effective pharmaceutics. Thus cinnamic acid esters of salicylanides are synthesized and evaluated for their antimicrobial activity in vitro. All the compounds are characterized by spectroscopic techniques such as FTIR, H1 NMR, C13 NMR and Mass. Molecular docking of these compounds is carried out in silico. Molecular docking of these compounds is carried out with enzyme β-Ketoacyl-acyl carrier protein synthase III from Escherichia coli (ecKAS III pdb id: 1HNJ) as a receptor responsible for growth of bacteria. The results showed that all Cinnamic acid esters of salicylanides are good inhibitors of β-Ketoacyl-acyl carrier protein synthase III.