Synthesis, Antimicrobial activity of piperazin-1-yl (3,4,5-Trimethoxyphenyl)Methanone Derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Synthesis, Antimicrobial activity of piperazin-1-yl (3,4,5-Trimethoxyphenyl)Methanone Derivatives

Author(s): S. M. Mallikarjunaa, C. Sandeepa and Basavaraj Padmashal i

Aromatic acid chlorides are coupling with Piperzain-yl(3,4,5-trimethoxyphenyl)methanone in presence of triethylamine base to yield trimethoxyphenyl piperzine derivatives 3a-j. The structures of all the synthesized compounds have been characterised by elemental analysis and spectral studies. All the compounds have been tested for antifungal activity of and anti bacterial activity. Compounds 3d, 3e and 3f showed good antifungal activity and compound 3b, 3c, 3d, 3g and 3h showed moderate anti bacterial activity.


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