Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


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Synthesis, antimicrobial and anthelmintic activity of some novel benzimidazole derivatives

Author(s): Srikanth Lingala, Raghunandan Nerella, K. R. S. Sambasiva Rao

New benzimidazole derivatives containing 4-chloropyridine-2-carbonyl and N-methyl picolinamide moieties in one side chain at 1H position of benzimidazoles (2- ((benzylthio)methyl)-1H-benzo[d]imidazol-1-yl)(4-chloropyridin-2-yl)methanones(3) have been synthesized as depicted in scheme-1. The intermediates and final compounds were purified and their chemical structures have been confirmed by IR, 1H NMR, and Mass spectral data. All the derivatives were examined for their anthelmintic activity against Indian adult earthworms (pheretima posthuma) at various concentrations (0.2% and 0.5%), antibacterial activity against B.subtilis, B.cereus, S.epidermidis, S.typhi, P.aeruginosa and K.pneumoniae and antifungal activity against A.flavus, F.oxysporium and P.notatum at a concentration of 2mg/ml. Most of the compounds tested have shown promising activities when compared with the standard drugs.


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