Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis, Antimicrobial and Anthelmintic Activity Studies of Some Novel Triazole Schiff and Mannich Bases

Author(s): Madhu Kumar Dogganal Jayappa, Jagadeesh Prasad Dasappa, Konambi Ramaiah Chandrashekar, Sana Sheik2, Kumar Chaluvaiah, Prashantha Naik

A series of new Mannich bases (E)-4-((3,4-dimethoxybenzylidene)amino)-3-methyl-1-(substituted methyl)-1H-1,2,4-triazole-5(4H)-thione (6a-e) & (7a-h) were synthesized by treating (E)-4-((3,4-dimethoxybenzylidene)amino)-3-methyl-1H-1,2,4-triazole-5(4H)-thione (5) with various substituted primary/ secondary amines and formaldehyde. The Schiff base was obtained by treating 3-methyl-4-amino-5-mercapto-1,2,4-triazole (3) with 3,4-dimethoxybenzaldehyde (4) in the presence of acid catalyst. The triazole (3) was prepared by treating acetic acid (1) with thiocarbohydrazide (2) at reflux temperature. The newly synthesized compounds were confirmed by spectroscopic techniques and screened for their antimicrobial and anthelmintic activity.


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