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Synthesis, antimicrobial and antifungal screening of novel chalcones containing imidazo[1,2-a] pyridine nucleus | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Synthesis, antimicrobial and antifungal screening of novel chalcones containing imidazo[1,2-a] pyridine nucleus

Author(s): R. Saddik, A. Gaadaoui, M. Koudad, A. Ousaid, A. Elaatiaoui, A. Hamal, A. Zarrouk, N. Benchat

A series of chalcones were prepared by reacting various 2-(phenyl) imidazo [1,2-a] pyridine-3-carbaldehyde with acetophenones in the presence of alcoholic alkali. The structure elucidation of synthesized compounds has been done on the basis of elemental analysis, infrared and 1H nuclear magnetic resonance spectroscopy and further supported by Mass spectrometry. All the compounds have been evaluated for their in vitro biological assay like antibacterial activity towards Gram positive and Gram negative bacterial strains and antifungal activity towards Aspergillus niger at a concentration of 40μg/ml. The biological activities of synthesized compounds were compared with standard drugs.


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