Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis, antimicrobial and anti-inflammatory activities of 2- N[aryl-methylidene]-6-fluoro-5-piperazinyl[1, 3]benzothiazole-2- amines

Author(s): M S Chaithanya, G Nagendrappa, V P Vaidya, L V G Nargund

3-Chloro-4-fluoroaniline 1 on reaction with potassium thiocyanate in glacial acetic acid yielded corresponding thiocyanate derivative 2, which upon oxidative cyclization with bromine in acetic acid yielded 2-amino-5-chloro-6-fluoro[2,1-b][1,3]benzothiazole 3. Compound 3 on reaction with various aromatic aldehydes yielded corresponding aryleneimines 4a-j, which upon reaction with piperazine in the presence of triethylamine gave the title compounds 5a-j. Thus synthesized compounds were characterized compounds by UV, IR, NMR and MASS spectral data. The title compounds were then evaluated for antibacterial, antifungal and anti-inflammatory activities


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