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Synthesis, antimicrobial and anti-inflammatory studies of isoxazole analogues of Rosuvastatin | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Synthesis, antimicrobial and anti-inflammatory studies of isoxazole analogues of Rosuvastatin

Author(s): Sanath Kumar Goud Palusa a,b, Rajgopal H. Udupi b*, Himabindu. V

Novel isoxazole analogues of Rosuvastatin compounds (14a-j) were synthesized by the cyclisation of allyl compounds with substituted pyrimidine oxime using chloromine-T in multiple steps. The synthesized compounds were evaluated for their in vitro antmicrobial and antiinflammatory activity. Some of the newly synthesized compounds showed good antimicrobial and anti-inflammatory activities.


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