Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis, anti-microbial evaluation and cytotoxicity bioassay of some synthesized novel pyridazine derivatives comparison to standard drugs

Author(s): Ahmed A. Fayed, Ahmed F. El-Farargy, Nabil M. Yousif, Farouk A. Gad and Atef A. Kalmouch

Pyridazines and their derivatives received tremendous attention with the recent discovery of biological activities such as anti-inflammatory, anti-epileptic, antibacterial, antibiotic, anti-depressant, anti-diabetic, anti-hypertensive, analgesic, anti-tumor, antiviral and anti-cancer.New series of pyridazine and pyrazinehave been synthesized and the structures of the new compoundswere established on the basis of 1H-NMR, mass (ES/MS), elemental analysis and IR spectral data. In vitro anti-microbial activity (MICactivity) was evaluated and compared with standard drugs Tertacyclineand Ketoconazole. Most of the compounds in the serieshave shown very interesting anti-microbial activity against both Gram-positive and Gram-negative organisms. The detailed synthesis, spectroscopic data and pharmacological properties are reported.


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