In the present research work a series of isoxazole derivatives have been synthesized. The isoxazole derivatives are prepared starting from ethylacetoacetate with triethyl orthoformate followed by cyclization and hydrolysis of ester to form 5-Methylisoxazole-4-carboxylic acid. Further the acid is converted into acid chloride followed by condensation leads to a new series of 5-methyl-N-(substituted aryl) isoxazole-4- carboxamides (9 a-f, 13 a-c). The structures of newly synthesized compounds are confirmed on the basis of IR, 1H NMR of spectral data. The newly synthesized title compounds were screened for their in vitro antimicrobial activity. The compounds N-(2-chloro-5-nitrophenyl)-5-methylisoxazole-4-carboxamide (9 e) and N-(4-cyano- 3-(trifluoro-methyl)-phenyl)-5-methylisoxazole-4-carbox-amide (9 f) are shown good antibacterial and anti fungal activity. The electrochemical reduction was carried out by using cyclic voltammetric technique and the effects of scan rate, sulphuric acid concentration and substitutents were studied. The overall electrode process was diffusion-controlled.
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