Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis, biological evaluation and molecular modeling study of substituted 1,2,4-triazole-3-acetic acid derivatives
Author(s): Hend A. A. Abd El-wahab, Hamdy M. Abdel-Rahman, Gamal-Eldin S. Alkaramany and Mahmoud A. El-GendyA series of 1,2,4-triazole-3-acetamides 3a-b, 1-acylated-1,2,4-triazole-3- acetamides 4a-b, ethyl 5-(2-substitutedacetamido)-1H-1,2,4-triazole-3-acetates 6, 7, 8, ethyl 1- substituted (carbamoyl and thiocarbamoyl)-5-amino-1H-1,2,4-triazole-3-acetates 9a-j and ethyl 5-(3(4- chlorophenyl)ureido-1H-1,2,4-triazol-3-acetate 10 were synthesized. The obtained compounds were evaluated for their anti-inflammatory. Most of the tested compounds exhibited significant anti-inflammatory activities with compounds 9a-j were better than indomethacin. None of the tested compounds showed significant antitumor activity. Finally docking of selected compounds was performed to COX-2 and COX-1 enzymes in order to rationalize the obtained antiinflammatory results and to predict the selectivity of the synthesized compounds.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 25868
Der Pharma Chemica received 25868 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
DOWNLOADS
