Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis, characterisation and antibacterial evaluation of chalcone derivatives linked with 2-trifluoromethyl furan

Author(s): M. Rajasekhar, T. S. V. Prasad Reddy, Anima Sunil Dadhich, B. Ram and B. Balram

The present paper describes the synthesis and antibacterial activity of 2-trifluoromethyl furan chalcones 7a-7r against a panel of two Gram-positive strains (Staphylococcus aureus and Streptococcus pyogenes) and two Gram-negative strains (Escherichia coli and Pseudomonas aeruginosa). The structures of the synthesized chalcones derivatives 7a-7r and its related intermediate compounds were confirmed by 1H NMR, Mass and IR spectral data. Claisen-Schmidt reaction of compound 6 with various aromatic and hetroaromatic aldehydes a-r was carried out by grinding (mortal and pestle) compound 6 in presence of NaOH at room temperature for 3-5 min resulting in the formation of chalcone derivatives 7a-7r. Within the series of chalcone derivatives, compounds 7p, 7q and 7r, exhibited excellent antibacterial activity (++++), while the compounds 7f, 7i, 7k, 7l, 7m, 7n showed good antibacterial activity (+++).


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