Synthesis, characterisation and biological evaluation of some new hydrazide hydrazones | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Synthesis, characterisation and biological evaluation of some new hydrazide hydrazones

Author(s): Lakkakula Vinay Kumar, Pujari Jagan Naik, Palthuru Saifulla Khan, Abbavaram Babul Reddy, Talapaneni Chandra Sekhar and Golla Narayana Swamy

Methyl acrylate on treatment with 4-chlorobenzenethiol gave methyl 3-[(4- chlorophenyl)thio]propanoate 1. The latter on oxidation with hydrogen peroxide gave methyl-3- [(4-chlorophenyl)sulfonyl]propanoate 2. 3-[(4-chlorophenyl)sulfonyl] propane hydrazide 3 was prepared from methyl3-[(4-chlorophenyl)sulfonyl] propanoate 2 by reaction with hydrazine hydrate. A series of new hydrazones 4a-h were prepared from 3-[(4- chlorophenyl)sulfonyl]propanehydrazide. The structural elucidation of these compounds was based on their IR, 1H NMR, and MS spectral data. These compounds were also screened for their antimicrobial activity against four bacteria and two fungi and some of the compounds found to have promising activity.


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