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Synthesis, characterisation of some derivatives of 3-[(4-chlorophenyl) sulfonyl] propane hydrazide | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Synthesis, characterisation of some derivatives of 3-[(4-chlorophenyl) sulfonyl] propane hydrazide

Author(s): L. Vinay Kumar, P. Jagan Naik, T. Chandrasekhar, A. Babul Reddy, M. Karuna sree, N. Penchalaiah, G. Narayana Swamy

Reaction of methyl acrylate with 4-chlorobenzenethiol gave methyl 3-[(4-chlorophenyl)thio]propanoate 1. The latter on oxidation with hydrogen peroxide gave methyl-3-[(4-chlorophenyl)sulfonyl]propanoate 2. 3-[(4- chlorophenyl)sulfonyl] propane hydrazide 3 was prepared from methyl-3-[(4-chlorophenyl)sulfonyl] propanoate 2 by reaction with hydrazine hydrate. A new series of derivatives were synthesised from 3-[(4-chlorophenyl)sulfonyl] propane hydrazide 3. The structural elucidation of these compounds was based on their IR, 1H NMR and Mass spectral data.


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