Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
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Abstract
Synthesis, characterization and antibacterial activity of alkyl, benzyl and chloro substituted benzyl derivatives of nitroketene dithioacetals
Author(s): L Sakthikumar, J Kavitha and R Mahalakshmi*Nitromethane (1) upon treatment with Carbon disulfide (2) under ice cold condition in presence of dry methanol / Potassium hydroxide gave dipotassium salt of nitroketene dithioacetal (3). Further treatment of dipotassium salt (3) with alkyl and substituted chloro benzyl bromide furnished bis S,S – alkyl and Substituted chlorobenzyl derivatives (4-10). The structure of the synthesised compounds was characterised using UV, IR, 1H and 13C NMR spectral evidences. The antibacterial activities of products (3-10) were evaluated using Disc-Diffusion method.
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Citations : 25868
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