Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis, Characterization and antibacterial Activity of Copper(II) Mixed Ligand Complexes with Salen Type Ligands and Dithiocarbamates

Author(s): Meftah Salah Gasibat, Eman Bashir Al-Melah and Hana Bashir Shawish*

Mixed ligand complexes of Cu(II) with salen type ligands, namely N, Nʹ-bis(salicylidene)-1,2-ethylenediamine (salen) and N, Nʹ-bis(salicylidene)-1,2-pheneylenediamine (salophen) as primary ligands and pyrrolidine dithiocarbamate (pdtc) as a secondary ligand were prepared. The structural characterization of the synthesized complexes was carried out via analytical as well as various spectral studies. The obtained results reinforce that stoichiometry of the mononuclear mixed ligand complexes can be represented as NH4[Cu(II)-Schiff base(L)-pdtc(B)] and both H2L and (B) ligands can act as tetra and bidentates respectively. Additionally, both the schiff bases and the secondary pdtc ligands bind with copper(II) ion to build a stable six, five, six and four membered chelate rings with an octahedral geometry. The mass spectral data confirms the monomeric structure of the metal complexes while the study of the conductivity measurement indicated the 1:1 electrolyte nature of the complexes. The free Salen type ligands and their mixed copper(II) complexes have been tested for their antibacterial activity by using disc diffusion method and the results discussed.


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