Indole-based chalcone derivatives were synthesized via the reaction of indole and 5-bromo-indole with phosphoursoxychloride in the present of DMF to form formayl indole using Vilsmeyer Haack formylation reaction and the intermediate compound were formed by using condensation reaction. Finally cyclization reaction to get the target compound. The structure of all the synthesized compounds were elucidated by spectral analysis using IR, 1H NMR, and 13C NMR, spectrometer, The synthesized compounds were also evaluated for their antibacterial activities against three bacterial strains using agar well diffusion method and their antibacterial activity were screened for against gram positive bacteria staphylococcus aureus and gram-negative bacteria Klebsiella pneumonia, and Escherichia coli bacterial species. The synthesized chalcone 3-(4,5-dihydro-1,3-diphenyl-1H-pyrazol-5-yl)- 1Hindole was found to be good inhibiting the growth of Staphylococcus auraes (S. auraes) and Klebsiella pneumonia (k.pnemonia) bacteria strain at the concentration of 10μg/ml shows good antibacterial activity with zone of inhibition 16μg/ml and 25μg/ml with compared to the standard drug gentamicin at the concentration of 10μg/ml with zone of inhibition 21μg/ml and 29μg/ml respectively, against most bacteria strains Compared to the standard drug. Therefore, this compound could be a good starting point to develop new compounds for treating these pathogenic diseases.
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