Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis characterization and anti-bacterial activity of novel chalcone derivatives of indole

Author(s): Naikal J. P. Subhashini, Thriveni T and Shivaraj

Biologically active novel chalcone derivatives of1-(4-(((1H-indol-3-yl)methylene)amino)phenyl)-3-aryl prop-2-en-1- one (6a-o) have been synthesised by Claisen-Schmidt condensation reaction.A simple condensation reaction of Schiff’s Base i.e., (E)-1-(4-(((1H-indol-3-yl)methylene)amino)phenyl)ethanone(4)witharyl aldehydes (5a-o)under basic conditions have been carried out. The synthesized chalcone derivatives have been analyzed by IR,1H-NMR, Mass, andelemental analysis. All the newly synthesized chalcone derivatives were screened for anti-bacterial activity against gram positive bacteria (S.aureus, B. subtilis) and gram negative bacteria (E. coli, K. pneumonia). It was found that some of thesechalcone derivatives showing the moderate activity.


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