Synthesis characterization and anti-bacterial activity of novel chalcone derivatives of indole

Naikal J. P. Subhashini; Thriveni T; Shivaraj

Abstract

Synthesis characterization and anti-bacterial activity of novel chalcone derivatives of indole

Author(s): Naikal J. P. Subhashini, Thriveni T and Shivaraj

Biologically active novel chalcone derivatives of1-(4-(((1H-indol-3-yl)methylene)amino)phenyl)-3-aryl prop-2-en-1- one (6a-o) have been synthesised by Claisen-Schmidt condensation reaction.A simple condensation reaction of Schiff’s Base i.e., (E)-1-(4-(((1H-indol-3-yl)methylene)amino)phenyl)ethanone(4)witharyl aldehydes (5a-o)under basic conditions have been carried out. The synthesized chalcone derivatives have been analyzed by IR,1H-NMR, Mass, andelemental analysis. All the newly synthesized chalcone derivatives were screened for anti-bacterial activity against gram positive bacteria (S.aureus, B. subtilis) and gram negative bacteria (E. coli, K. pneumonia). It was found that some of thesechalcone derivatives showing the moderate activity.

PDF

Select your language of interest to view the total content in your interested language