The present work includes the synthesis of glycine and L-amino acid derivatives 6-10 (A,B) via Schiff`s bases 3 (A,B), which were obtained from the reaction of 2-aminopyridine 2 with benzaldehyde 1A or 4-chlorobenzaldehyde 1B. The reaction of 3 (A,B) with benzoyl chloride yielded benzamide derivatives 5 (A,B). The synthesis of 6-10 (A,B) has been performed by the reaction of 5 (A,B) with (glycine, L-alanine, L-phenylalanine, L-aspartic acid and L-asparagine). Infrared and nuclear magnetic spectroscopic techniques Fourier Transform Infrared (FT-IR), Proton Nuclear Magnetic Resonance (1H-NMR) and Carbon-13 nuclear magnetic resonance (13C-NMR) were used to characterize the newly synthesized compounds. The antibacterial activity of final products has been evaluated against two kinds of Gram-positive and Gram-negative bacteria (Staphylococcus aureus and Klebsiella pneumonia). Overall, results indicate a lower and moderate antibacterial activity in comparison with meropenem as a reference against both bacteria. The highest activity was obtained using the compound 7B for both kinds of bacteria and 6A for only K. pneumonia.
Select your language of interest to view the total content in your interested language