Synthesis, Characterization and Antibacterial Activity of Some Amino Acid Derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X


süperbetin giriş

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

agariookey oyna istanbul okey


Synthesis, Characterization and Antibacterial Activity of Some Amino Acid Derivatives

Author(s): Jawad Kadhum Shneine, Dina Ziad Qassem, Suhad Saad Mahmoud

The present work includes the synthesis of glycine and L-amino acid derivatives 6-10 (A,B) via Schiff`s bases 3 (A,B), which were obtained from the reaction of 2-aminopyridine 2 with benzaldehyde 1A or 4-chlorobenzaldehyde 1B. The reaction of 3 (A,B) with benzoyl chloride yielded benzamide derivatives 5 (A,B). The synthesis of 6-10 (A,B) has been performed by the reaction of 5 (A,B) with (glycine, L-alanine, L-phenylalanine, L-aspartic acid and L-asparagine). Infrared and nuclear magnetic spectroscopic techniques Fourier Transform Infrared (FT-IR), Proton Nuclear Magnetic Resonance (1H-NMR) and Carbon-13 nuclear magnetic resonance (13C-NMR) were used to characterize the newly synthesized compounds. The antibacterial activity of final products has been evaluated against two kinds of Gram-positive and Gram-negative bacteria (Staphylococcus aureus and Klebsiella pneumonia). Overall, results indicate a lower and moderate antibacterial activity in comparison with meropenem as a reference against both bacteria. The highest activity was obtained using the compound 7B for both kinds of bacteria and 6A for only K. pneumonia.


rokettube brazzers

Turkish dental care is known to be affordable compared to other countries. If you want an affordible dentist Turkey, check out periodonta. It is heavily recommended for dental patients visiting Turkey