The growth of new compounds, chalcones has revealed that they acquire a wide variety of biological activities viz., antibacterial, anti-inflammatory, antitumor and antimalarial etc. Chalcones having an α, β unsaturated carbonyl group are versatile synthons for various chemical transformations. The chemistry of chalcones has taken an important place in organic chemistry; the research in this area is encouraged because of development of bacterial resistance to widely used antibiotics of this type. The present paper describes the synthesis and antibacterial activity of novel chalcone derivatives derived from 3-methoxy-4-hydroxy-acetopheneone.
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