Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Synthesis, Characterization and Antibacterial Studies of Oxovanadium (IV) and Copper(II) Schiff Base Complexes Derived from Benzoin and Anthranilic Acid-A Tridentate Ligand

Author(s): Gayathri N, Suresh MS, Prakash V

Oxovanadium VO(IV) and Cu(II) complexes with a tridentate Schiff base derived from benzoin and 2-aminobenzoic acid have been synthesized and characterized. The nature of the bonding and geometry of the complexes have been deduced from elemental analysis, spectral (UV, FTIR, ESR) analysis, magnetic susceptibility measurements, molar conductivity measurements and thermal analysis. The magnetic moments and electronic spectra of the complexes indicate octahedral geometry for both the complexes having molecular formula [VOL(H2O)2] and [CuL(H2O)3]. Both the complexes were found to be non-electrolytic in nature. The IR spectra reveals the involvement of azomethine nitrogen (-C=N-) oxygen atoms from hydroxyl group and carboxylate ion are coordinated to the metal, with coordinated water. The thermal decomposition of the complexes yields the oxides of metal as the stable residue. The ESR spectra of both the complexes in dimethyl sulfoxide (DMSO) at 77K were recorded and their salient features are reported. The metal complexes have been screened for their antibacterial activity against organisms like Escherichia coli, Staphylococcus aureus, Serattai sp, Pseudomonas aeruginosa and Bacillus cereus by disc diffusion method and the results revealed that the complexes are more potent than the ligand.


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