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Synthesis, characterization and antimalarial screening of some new N-[(2-chloroquinolin-3-yl)methylene]benzenamines | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Synthesis, characterization and antimalarial screening of some new N-[(2-chloroquinolin-3-yl)methylene]benzenamines

Author(s): Yogesh Murti, Sujeet K. Gupta & Devender Pathak

A convenient synthesis of N-[(2-chloroquinolin-3-yl)methylene]benzenamines (1-12) (Schiff’s bases), is achieved in two steps. Acetanilide on reaction Vilsmeier-Haack reagent give 2-chloro- 3-formyl quinoline followed by reaction with different substituted aryl amines. All the compounds have been characterized by their melting point, elemental analysis, IR, 1H NMR & MASS spectra. The synthesized compounds have been screened for antimalarial activity.


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