Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis, characterization and antimicrobial activities of 4-Benzylidene-1-{4-[3-(substituted phenyl)prop-2-enoyl]phenyl}-2-phenyl-imidazol-5-one

Author(s): R. A. Shah, P. S. Patel, D. K. Trivedi, P. J. Vyas

Some 4-benzylidene-1-{4-[3-(substituted phenyl)prop-2-enoyl]phenyl}-2-phenyl-imidazol-5-one were synthesized by the condensation of 1-(4-acetylphenyl)-4-benzylidene-2- phenyl- imidazol-5- one with various aldehydes. The intermediate 1-(4-acetylphenyl)-4-benzylidene-2- phenyl- imidazol- 5-one was synthesized by the condensation of 4-benzylidene-2- phenyl -1,3-oxazol-5-one with 1-(4- aminophenyl) ethanone in presence of pyridine. The products were characterized by spectral and analytical data. Most of the tested compounds showed promising antibacterial and antifungal activity.