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Synthesis, characterization and antimicrobial activities of N-substituted indoline derivatives of sultams | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis, characterization and antimicrobial activities of N-substituted indoline derivatives of sultams

Author(s): S. Harikrishna and L. K. Ravindranath

A new class of N-Substituted Indoline derivatives of Sultams namely (E)-2-benzyl-N'-(N-Substituted-2-oxoindolin-3- ylidene)-3-phenyl-2,3,4,5-tetrahydrobenzo[f][1,2,4]thiadiazepine-5-carbohydrazide 1,1-di oxide (10-12) were synthesized through a process of mannich reaction where hydrazone derivative of Sultam (9) get reacted with pipperidine, Morpholine and Methylpipperazine to afford the title compounds. The structure of each novel compound was elucidated on the basis of elemental analysis, IR 1H NMR and Mass spectral Analysis. All the newly synthesized compounds were screened for their antibacterial and antifungal activities. Antimicrobial studies revealed that the pharmacological properties of the synthesized compounds were enhanced by introducing pipperidine, Morpholine, Methylpipperazine substituents.


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