Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis, characterization and antimicrobial activity of novel biphenyl tetrazoles

Author(s): Somisetti Narender Rao, T. Ravisankar, J. Latha, K. Sudhakar Babu

A series of novel biphenyl tetrazoles compounds have been prepared from the secondary amides by the reaction with phosphorous pentachloride and sodium azide. These tetrazoles compounds were subjected to benzylic bromination and further condensed with n-methyl piperazine to afford compounds 6a-j and 7. The structures of the newly synthesized compounds were characterized by NMR, Mass, IR spectral data and elemental analysis. All the synthesized compounds were screened for their antibacterial activity.