Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Synthesis, Characterization and Antimicrobial Activity of Some New Substituted Quinoline Hydrazones

Author(s): Kanu D Katariya, Shailesh R Shah

Several 6-bromo-2-methyl-4-(2-(1-phenylethylidene)hydrazinyl) quinolines have been synthesized and characterised by using Infra-Red (IR), Proton nuclear magnetic resonance (1H NMR), Carbon-13 nuclear magnetic resonance (13C NMR) and mass spectral analysis. Their in vitro antimicrobial activities have been evaluated on the pathogenic fungi Fusarium pallidoroseum and Candida albicans and on the Gram-positive bacteria Staphylococcus aureus and Bacillus subtilis and the Gram-negative bacteria Escherichia coli and Pseudomonas aeruginosa. The new bromo quinoline compounds are found to possess a broad spectrum of antimicrobial activities.


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