Chalcone have displayed an impressive array of biological importance. A series of Chalcone were prepared by Claisen-Schmidt condensation from 1-(4-acetylphenyl)-3-chloro-4-(4- hydroxyphenyl) azetidin-2-one with appropriate aromatic aldehydes in the presence of aqueous solution of alkali and ethanol at room temperature. The synthesized compounds were characterized by means of their IR, 1H-NMR spectral data and elemental analysis. All the compounds were tested for their antibacterial and antifungal activities by broth dilution method.
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