Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis, characterization and anti-microbial activity of tetazolium salt containing 8-hydroxy quinoline moiety in ligand and its metal chelates

Author(s): R. T. Vashi and N. M. Sheth

Novel ligand containing 8-hydroxyquinoline (HQ) moiety was prepared and characterized. For synthesis of ligands a hydroxyquinoline-5-carbaldehyde was treated with phenyl hydrazine to synthesis corresponding hydrazone. The hydrazone was condensed with diazonium salt of sulfanilamide to synthesis formazan. The formazan was converted to corresponding tetrazolium sals by using hydrogen peroxide, hydrobromic acid and ferrous sulphate. The isolated tetrazolium salt of 8-hydroxyquinoline derivative was designated as L1. The novel ligand L1 undergo the chelating reaction with Cu (II), Ni (II), Co (II), Mn (II), Zn (II) and Fe (III) salts to prepare transition metal chelates. These chelates were characterized by physicochemical methods such as elemental analysis, magnetic susceptibility, IR and electronic spectral data. The stoichiometry of the complex has been found to be 1: 2 (Metal: ligand) for divalent and 1:3 for trivalent ions. An octahedral geometry around Co (II), Ni (II),Fe (III) and Mn (II), distorted octahedral geometry around Cu (II) and tetrahedral geometry around Zn (II) have been proposed. The antimicrobial activity of ligand and its metal chelates was conducted against various bacteria.


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