Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis, Characterization and Antimicrobial Activity Studies of Novel Pyrazole Derivatives

Author(s): Kishan N, Renuka N, Ajay Kumar K, Jayadevappa HP

An efficient and accessible procedure for the synthesis of substituted pyrazoles was described. The method involves cyclocondensation reaction of chalcones with 2,4-dimethylphenylhydrazine hydrochloride in the presence of catalytic amount of hydrochloric acid to obtain pyrazole derivatives in good yields. The synthesized new compounds were characterized by spectral studies and elemental analysis; and evaluated in vitro for their antimicrobial susceptibilities.


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