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Synthesis, characterization and antimicrobial evaluation of dicoumarinyl substituted pyrazolyl pyridines
Author(s): Kaushik N. Kundaliya, Yogita L. Chovatiya, Niraj H. Patel and D. I. Brahmbhatt
The synthesis of various 2,6-di(coumarin-3-yl)-4-(1-phenyl-3–aryl-1H-pyrazol-4-yl)pyridines (5a-r) have been carried out by the reaction of 3-coumarinoyl methyl pyridinium bromide salts (4a-c) with various 3-[3-(1-phenyl-3- aryl-1H-pyrazol-4-yl) acryloyl] coumarins (coumarin chalcones) (3a-f) in the presence of ammonium acetate in refluxing acetic acid. The synthesized compounds were fully characterized by IR, 1H-NMR, 13C-APT and representative Mass spectral data. The synthesized compounds were screened for in vitro antimicrobial activity using Broth micro dilution method.