The endeavour of the present work is to synthesize some biologically active Schiff bases and their organotin (IV) complexes derived from substituted o-vanillin and thiophene-2- carboxylic acid hydrazide. Organotin (IV) complexes were synthesized by reacting R2SnCl2 (Where, R=Ph, Bu, Et and Me) with ligands in 1:1 ratio in methanol as solvent. The biological activity of Schiff base ligands enhanced on complexation under similar experimental conditions. The newly synthesized compounds were characterized by elemental analyses, UV-Vis, IR and NMR (1H, 13C and 119Sn) spectral techniques.
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