Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis, Characterization and Antimicrobial Evaluation of Schiff base Complexes Derived from [2,2ˊ-(ethylenedioxy)bis(ethylamine)] and 5-Chlorosalicylaldehyde

Author(s): Jai Devi, Suman Devi

In this abstract a brief account is given of the synthesis, stereochemistry and antibacterial behavior of organotin (IV) complexes of Schiff base derived from 2,2′-(ethylenedioxy)bis(ethylamine) and 5-chlorosalicylaldehyde in 1:2 molar ratio. The compounds have been characterized by spectroscopic techniques (UV-Vis, IR and NMR). The penta coordinated complexes were obtained which coordinate through azomethine nitrogen and hydroxyl oxygen. The synthesized compounds have been investigated for their antimicrobial activity against Gram positive bacteria viz. Staphylococcus epidermidis, Staphylococcus hominis and Gram negative bacteria viz. Pseudomonas aeruginosa and Klebsiella pneumonia and fungus Aspergillus niger. The studies established that phenyl derivatives exhibited better antibacterial activities than standard drug ciprofloxacin. For most of the complexes, higher activity was displayed on coordination with silicon atom than respective ligand due to lipophilic nature of tin atom which favours the permeation of the complexes in the cell to be used as the bactericides.