GET THE APP

Synthesis, Characterization and Antimicrobial Evaluation of Schiff base Complexes Derived from [2,2??-(ethylenedioxy)bis(ethylamine)] and 5-Chlorosalicylaldehyde | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis, Characterization and Antimicrobial Evaluation of Schiff base Complexes Derived from [2,2??-(ethylenedioxy)bis(ethylamine)] and 5-Chlorosalicylaldehyde

Author(s): Jai Devi, Suman Devi

In this abstract a brief account is given of the synthesis, stereochemistry and antibacterial behavior of organotin (IV) complexes of Schiff base derived from 2,2′-(ethylenedioxy)bis(ethylamine) and 5-chlorosalicylaldehyde in 1:2 molar ratio. The compounds have been characterized by spectroscopic techniques (UV-Vis, IR and NMR). The penta coordinated complexes were obtained which coordinate through azomethine nitrogen and hydroxyl oxygen. The synthesized compounds have been investigated for their antimicrobial activity against Gram positive bacteria viz. Staphylococcus epidermidis, Staphylococcus hominis and Gram negative bacteria viz. Pseudomonas aeruginosa and Klebsiella pneumonia and fungus Aspergillus niger. The studies established that phenyl derivatives exhibited better antibacterial activities than standard drug ciprofloxacin. For most of the complexes, higher activity was displayed on coordination with silicon atom than respective ligand due to lipophilic nature of tin atom which favours the permeation of the complexes in the cell to be used as the bactericides.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Recommended Conferences
Google Scholar citation report
Citations : 23677

Der Pharma Chemica received 23677 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry