Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis, characterization and antimicrobial Studies of (N'1E, N’6E)-N'1, N’6-bis((2-hydroxyquinolin-3-yl)methylene)adipohydrazide

Author(s): K. Siddappa, Mallikarjun Kote

The Cu(II), Co(II), Ni(II), Zn(II), Cd(II), Hg(II), and Mn(II)complexes of Schiff base (N'1E,N'6E)-N'1,N'6-bis((2- hydroxyquinolin-3-yl)methylene)adipohydrazide has been synthesized and characterized by various spectral techniques. The complexes were prepared by reacting the ligand and metal chloride of Cu(II), Co(II), Ni(II), Zn(II), Cd(II), Hg(II), and Mn(II) in ethanol to get a series of mononuclear complexes. The complexes were characterized by CHN analysis, conductivity measurements, magnetic susceptibility, IR, NMR, ESR, UV-Vis and X-ray powder diffraction studies. By these spectral studies it is found that Cu(II), Co(II), Ni(II), Zn(II), Cd(II) Hg(II) and Mn(II) complexes have exhibited octahedral geometry. The ligand and its metal complexes have been screened for their antimicrobial activities. The prepared ligand shows low activity and its metal complexes shows moderate to good activity.


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