Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Abstract

Synthesis, Characterization and Antimicrobial Studies on Some Pyridoxylidene-sulphamethoxazole Schiff Base Tellurium (IV) Complexes

Author(s): Deepak Sonu Chauhan, Krishna K Verma, Sapana Garg

A monobasic bidentate Schiff base Pyridoxylidene-sulphamethoxazole (HPL-SMZ) synthesized from sulphamethoxazole and pyridoxal, form complexes with aryltellurium (IV) trichlorides and diaryltellurium (IV) dichlorides of the type PL-SMZ.RTeCl2 and PL-SMZ.R2TeCl (R=4-methoxyphenyl, 4-ethoxyphenyl, 4-hydroxyphenyl and 3-methyl-4-hydroxyphenyl). They have been characterized by elemental analyses, molar conductance, Fourier Transform Infrared Spectroscopy (FTIR) and Proton Nuclear Magnetic Resonance (1HNMR) spectroscopy. The spectral studies predict the coordination of tellurium through phenolic oxygen after deprotonation and nitrogen of the azomethine group, thus giving pentacoordinated tellurium (IV) complexes probably in a distorted trigonal bipyramidal environment. The complexes were evaluated for their antifungal and antibacterial activities and observed to be more active as compared to parent Schiff base and aryltellurium chlorides.


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