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Synthesis, Characterization and Antioxidant Activity of Novel 2-Aryl Benzothiazole Derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Abstract

Synthesis, Characterization and Antioxidant Activity of Novel 2-Aryl Benzothiazole Derivatives

Author(s): Amrita Parle, Shaista Amin

In the present study, a series of benzothiazole derivatives were synthesized. Reactions were monitored using thin layer chromatography technique and the newly synthesized derivatives were characterized by ATIR and Proton Nuclear Magnetic Resonance (1H-NMR) techniques. Antioxidant assay was performed using 2,2′-Azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) method and 2,2-Diphenyl-1- Picrylhydrazyl (DPPH) method. The antioxidant activity was found to be better in ABTS assay than DPPH assay. It was found that the synthesized benzothiazole derivatives showed significant radical scavenging potential.


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