Synthesis, Characterization and Antioxidant Activity of pyrimidinone Derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
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Synthesis, Characterization and Antioxidant Activity of pyrimidinone Derivatives

Author(s): Jyothi N Rao* and Sujatha K

Three component Biginelli reactions is carried out using aromatic aldehydes, aliphatic amides and 1, 3-dicarbonyl compound to afford corresponding dihydropyrimidinones in the presence of MgBr2 as an efficient catalyst. The advantage of this method includes high yield, environment friendly, reduced reaction time and operational simplicity. Representative compounds of the synthesized products were tested and evaluated as antioxidant agents. Most of the synthesised compounds have potent antioxidant activity.

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