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Synthesis Characterization and antitumor activity of thiazole derivatives containing indole moiety bearing-tetrazole | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis Characterization and antitumor activity of thiazole derivatives containing indole moiety bearing-tetrazole

Author(s): S. Muralikrishna, P. Raveendrareddy, L. K. Ravindranath, S. Harikrishna and P. Jagadeeswara Rao

Schiff base synthesis of thiazole derivatives containing Indole moiety bearing tetrazole ring were synthesised by the condensation of 2-(3-(3chloro -1-(4-substitued phenyl )-tetrazole -2-yl(1H-Indole –yl Aceto hydrazone with potassium thio cyanide and substituted ketones.To this reaction was subjected in schiff base reaction .The structure of these newly synthesized compounds were characterised by 1H NMR,13CNMR ,Mass ,IR, and elemental analysis.


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