Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

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Synthesis, characterization and anti-tumour activity of VOF3 and Cu (II) porphyrine complexes

Author(s): Fahmideh Shabani, Shahriar Ghammamy

Metal complexes of the ligand, 10, 15, 20-Tetra-p-tolyl-porphyrine abbreviated as H2TPP were prepared by reaction of salts of VOF3 and Cu (OAC) 2 with H2TPP in dry DMF. Characterization of the ligand and its complexes was made by microanalyses, FT-IR, 1H NMR and UV–Visible spectroscopy. These new complexes showed excellent anti-tumor activity against two kind of cancer cells that are K562 (human chronic myeloid leukemia) cells and Jurkat (human T lymphocyte carcinoma) cells.


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