A series of 2,5–disubstituted 1,3,4-oxadiazoles 5a-k have been synthesized by the condensation of p-phenyl sulphonyl benzohydrazide with various aromatic acids in the presence of phosphorous oxy chloride. The structure of compounds was analyzed by IR, Hl NMR and mass spectral data. The compounds 5a-k were screened for antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pyogene and antifungal activity against Aspergillus Niger, Helminthosporium oryzae using disc diffusion method. Some of the compounds showed prominent activity against bacteria and fungi.
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