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Synthesis, characterization and biological activities of 2,5-disubstituted 1,3,4-oxadiazoles | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis, characterization and biological activities of 2,5-disubstituted 1,3,4-oxadiazoles

Author(s): Karuna Sree Merugu, Aravind Kurnool, Vinay Kumar Lakkakula, Jagan Naik Pujari, Babul Reddy Abbavaram and Narayana Swamy Golla

A series of 2,5–disubstituted 1,3,4-oxadiazoles 5a-k have been synthesized by the condensation of p-phenyl sulphonyl benzohydrazide with various aromatic acids in the presence of phosphorous oxy chloride. The structure of compounds was analyzed by IR, Hl NMR and mass spectral data. The compounds 5a-k were screened for antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pyogene and antifungal activity against Aspergillus Niger, Helminthosporium oryzae using disc diffusion method. Some of the compounds showed prominent activity against bacteria and fungi.


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