GET THE APP

Synthesis, characterization and biological activities of 2,5-disubstituted 1,3,4-oxadiazoles | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission Systemof respective journal.

Abstract

Synthesis, characterization and biological activities of 2,5-disubstituted 1,3,4-oxadiazoles

Author(s): Karuna Sree Merugu, Aravind Kurnool, Vinay Kumar Lakkakula, Jagan Naik Pujari, Babul Reddy Abbavaram and Narayana Swamy Golla

A series of 2,5–disubstituted 1,3,4-oxadiazoles 5a-k have been synthesized by the condensation of p-phenyl sulphonyl benzohydrazide with various aromatic acids in the presence of phosphorous oxy chloride. The structure of compounds was analyzed by IR, Hl NMR and mass spectral data. The compounds 5a-k were screened for antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus pyogene and antifungal activity against Aspergillus Niger, Helminthosporium oryzae using disc diffusion method. Some of the compounds showed prominent activity against bacteria and fungi.


PDF

Select your language of interest to view the total content in your interested language

30+ Million Readerbase
SCImago Journal & Country Rank
Google Scholar citation report
Citations : 25868

Der Pharma Chemica received 25868 citations as per Google Scholar report

Der Pharma Chemica peer review process verified at publons
Der Pharma Chemica- Journals on pharmaceutical chemistry