Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry
ISSN: 0975-413X
Abstract
Synthesis, Characterization and Biological Activity of Novel Podophyllotoxin Bearing Pyrimidine Moieties
Author(s): Paniraj AS, Sowmya PT* and Lokanatha Rai KMPodophyllotoxin, a naturally occurring aryl tetralin-type lignan obtained from Podophyllin, an ethanolic extract of Podophyllum peltatum L.(syn.P.hexandnum Royle), exhibits marked biological activity as strong antineoplastic drugs and antiviral agents. Chemical transformations performed on podophyllotoxin resulted in analogs which also display potent cytotoxic, antiviral, and immunosuppressive activities. At present, ten novel compounds of podophyllotoxin bearing pyrimidine moieties were synthesized and characterized by 1H and 13C-NMR, elemental analysis, and Mass spectroscopy. All the synthesized compounds were tested for antimicrobial activities.
Select your language of interest to view the total content in your interested language
Google Scholar citation report
Citations : 25868
Der Pharma Chemica received 25868 citations as per Google Scholar report
Der Pharma Chemica peer review process verified at publons
DOWNLOADS
