Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Synthesis, characterization and biological activity of some molybdenum(VI) complexes

Author(s): Keerti Saraswat, Ravi Kant

Synthesis of cis-dichloro/dibromodioxidobis(2-amino-6-substitutedbenzothiazole) molybdenum(VI) complexes have been carried out by the reaction of ether extract of MoO2X2 (where X = Cl, Br) with ethanolic solution of 2-NH2-6-Rbenzothiazole (where R = NO2, CH3, OCH3, OC2H5) in 1:2 molar ratio. The newly synthesized compounds were characterized by their elemental analysis and spectral studies such as IR, 1H and 13C{1H} NMR spectroscopy shows monodentate nature of benzothiazole ligands. Distorted octahedral geometry around the central molybdenum atom in these cis-dichloro/dibromodioxidobis(2-amino-6-substitutedbenzothiazole) molybdenum(VI) complexes has been observed. The synthesized complexes were also screened for their antibacterial, antifungal, anti-inflammatory, antiulcer and antitumor activities using standard methods.


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