Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis, characterization and biological activity of some new pyrazino[2,1- b]quinazolinone derivatives

Author(s): M. A. Zein and H. A. Abubshait

Amonalysis of 2-(chloromethyl)-4-oxo-benzoxainone(1) with ammonium acetate under fusion gave the corresponding 2-(aminomethyl)-4(3H)-quinazolinone(2). 4-Aryl-1H-pyrazino[2,1-b]quinazolin-6(2H)-ones(3a-d) were prepared via treatment of 3 with ω-bromomethyl arylketones in presence of fused sodium acetate in acetic acid. Acetylation and alkylation of 3 with acetic anhydride, acetic anhydride-fused sodium acetate and alkyl halides yielded the corresponding monoacetyl, diacetyl derivatives(4,5) and N-alkyl derivatives(6).The mass spectral fragmentation patterns of some prepared compounds have been investigated in order to elucidate the structure of the synthesized compounds. Antimicrobial activities were assayed against test bacteria and fungi