Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

Abstract

Synthesis, Characterization and Biological Activity Study of Some New Compounds Containing Amine and Azomethine Group and their Platinum II Complexes

Author(s): Bushra K. Al-Salami, Ahmed L. Al-Fadhly and Adil A. Al-Fregi

New platinum (II) complexes were synthesized from two types of amine compounds as Ligands. The first type derived from the reaction of ethylenediamine with 3-phenylpropylbromide with molar ratio [1:1] and [1:2] respectively , the other type was new Schiff base derived from condensation of o-phenylenediamine with [ 2- furaldehyde, ferrocenecarboxaldehyde and acetyl ferrocene ] with different molar ratio [ 1:1 and 1:2 ]. The ligands and their platinum (II) complexes were characterized by FT-IR , UV-Vis , 1H-NMR and CHN elemental analysis . The spectroscopic analysis results demonstrate that the coordination sites are the nitrogen atom of NH2 groupor the azomethine nitrogen atom of the Schiff base . The conductivity values between 3.00 – 7.70 ohm-1.cm-1.mol-1in DMSO imply the presence of non-electrolyte species. With the help of different spectral like IR , UV-Vissible , 1H-NMR , CHN the geometrical structure of the complexes was proposed to be a square planar . Antibacterial activity of synthesized amino compounds and their complexes were tested against Staphylococcus aureus (+ev) gram and Escherichia coli (-ev) gram . The DNA cleavage activity of the complexes were assayed using UV-Vis spectrum. The result shows that there was overlap between the complexes and human DNA.


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