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Synthesis, characterization and biological applications of substituted benzohydrazide derivatives | Abstract

Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry

ISSN: 0975-413X

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Abstract

Synthesis, characterization and biological applications of substituted benzohydrazide derivatives

Author(s): S. Veeramanikandan and H. Benita Sherine

In the present article, a series of Schiff bases have been derived from aromatic aldehydes with acid hydrazide and using concentrated hydrochloric acid as catalyst. The synthesized compounds are (E)-4-Chloro-N?¹-(3,4- dimethoxybenzylidene)benzohydrazide(S1), (E)-4-Chloro-N?¹-(2,5-dimethoxybenzylidene)benzohydrazide(S2), (E)-4- Chloro-N?¹-(thiophene-2-ylmethylene) benzohydrazide(S3) and (E)-4-Chloro-N?¹-(4-chlorobenzylidene) benzohydrazide (S4) were characterized through FT-IR, 1H NMR and 13C NMR. These synthesized compounds have been screened for antimicrobial activity against S. aureus, E. coli and A. niger. The antioxidant activity of Schiff bases were investigated by DPPH radical scavenging method using UV spectrum. The designed compounds were further subjected for molecular docking studies for 2NSD protein in Mycobacterium tuberculosis by Discover studio 2.1version software.


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