Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis, Characterization and Biological Evaluation of DHA Based Schiff Base Motifs

Author(s): Dhananjay G Palke, Shridhar D Salunke

A new series of compounds of Dehydroacetic acid (DHA) based Schiff bases derived from aromatic primary amines were synthesized and characterized by elemental and spectral (IR, 1H-NMR) analysis. The signals of 1H-NMR spectrum and characteristic peaks in IR spectra are used for the determination of molecular structure of Schiff bases. The biological activities of synthesized compounds have been screened in vitro against Escherichia coli, Staphylococcus aureus, Bacillus subtilis bacterial species, Candida albicans and Aspergillus niger fungal organism and found to exhibit strong antifungal activity than antibacterial activity. Among the studied motifs, the compound L1 3-((E)-1-(4H-1,2,4-triazol- 4-ylimino)ethyl)-4-hydroxy-6-methyl-2H-pyran-2-one depicted discerning antifungal and antibacterial activities.