Der Pharma Chemica
Journal for Medicinal Chemistry, Pharmaceutical Chemistry, Pharmaceutical Sciences and Computational Chemistry


Synthesis, Characterization and Biological Evaluation of Functionalized Derivatives of Versatile Synthon 4,4'-Difluoro chalcone

Author(s): Seranthimata Samshuddin, Badiadka Narayana, Balladka Kunhanna Sarojini,Hemmige S. Yathirajan and Ramappa Raghavendra.

Some functionalized fluorinated derivatives are prepared by condensing 4,4'-difluoro chalcone with hydrazine derivatives, o-phenylenediamine, ammonium acetate/acetic acid, ethyl cyanoacetate, malononitrile, acetylacetone, esters of acetoacetic acid, acetoacetanilde, aminoguanidine hydrochloride, urea and thiourea. All these derivatives are characterized by NMR, IR, mass spectral and also some of them by single crystal XRD data. All the synthesized products are screened for their in vitro antimicrobial and antioxidant properties. Majority of the tested compounds exhibited significant antimicrobial activity and some of them showed DPPH scavenging activity.