To synthesize new hydrazone derivatives of naproxen with enhanced anti-inflammatory activity and devoi d the ulcerogenic side effects. Hydrazones were synthesiz ed by conjugation of naproxen hydrazide with seven natural and synthetic aldehyde and ketone by using glacial acet ic acid as catalyst. The synthesis has been carried out following simple methodology in excellent isolated yields.The structure of the synthesized derivatives has been characterized by elemental microanalysis (CHN), FTIR Spectroscopy , and other physicochemical properties.The anti- inflammatory activity of the synthesized compounds was evaluated in vivo using the egg-white induced e dema model in rats, and the results of the biological assay wa s found to be comparable to Naproxen in this regard . The synthesizedhydrazone of naproxen hydrazides with th eir pronounced anti-inflammatory activity can enhan ce the anti-inflammatory activity of naproxen to a varying degree according to the type of aldehyde or ketone used.
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